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Use of opioids for an extended period of time may influence the hypothalamic-pituitary-gonadal axis, leading to androgen deficiency that may manifest as symptoms as low libido, impotence, erectile dysfunction, amenorrhea, or infertility

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Focusing on ferroptosis-related pathways, including the system Xc-/GSH/GPX4 axis, iron metabolism, and inflammatory cytokines, may provide novel therapeutic strategies for managing OA

Statements Author contributions WG and QL conceived and designed the scope of the review

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